Antimicrobials
Clarithromycin

Clarithromycin

Medium
Moderate (40 to 70%)
$

Spectrum of Activity

Dosing

General Information

Monitor QTc in patients with increased risk.

  • Prolongation of QTc interval
  • Drug interactions

Recommend review of patient medications due to high frequency of significant interactions

  • CYP450 interactions ++

  • Other QTc prolonging agents

  • Statins - increased rhabdo

  • CCBs - hypotension, AKI

  • Colchicine - increased bone marrow toxicity

  • Increased anticonvulsant levels

  • Increased tacrolimus levels

Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing.

Antimicrobial class: Macrolide.