Monitor QTc in patients with increased risk.
Recommend review of patient medications due to high frequency of significant interactions
CYP450 interactions ++
Other QTc prolonging agents
Statins - increased rhabdo
CCBs - hypotension, AKI
Colchicine - increased bone marrow toxicity
Increased anticonvulsant levels
Increased tacrolimus levels
Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing.
Antimicrobial class: Macrolide.