Antimicrobials
Ciprofloxacin

Ciprofloxacin

High
Moderate (40 to 70%)
IV:$ PO:$

Spectrum of Activity

Dosing

General Information

Monitor QTc in patients with increased risk.

  • QTc prolongation

  • Dysglycemia

  • Tendinopathy and rupture

  • GI upset

  • Rash

  • Retinal detachment

  • CNS toxicity including confusion, psychosis

  • Weakness exacerbation in myasthenia gravis

CYP1A2 inhibitor - Multiple interactions possible.

QTc prolongation - Increased risk with other agents that prolong QTc.

Divalent & trivalent cations including Al, Ca, Fe, Mg (antacids, dairy products, iron supplements, some enteral feeds) - Decreased absorption.

Cyclosporine - Increased levels of cyclosporine.

Warfarin - Increased INR.

Methadone - Lowered seizure threshold.

Antimicrobial class: Fluoroquinolone.