Cefuroxime

C difficile risk
Medium
Oral Bioavailability
Moderate

Dosing

750-1500mg IV q8h

500mg PO q12h

eGFR 0 - 10eGFR > 10250mg PO q24h500mg PO BID

eGFR 0 - 10eGFR 10 - 20eGFR > 200.75-1.5g IV q24h0.75-1.5g IV q12h0.75-1.5g IV q8h

750-1500mg IV q24h

750mg PO

Give dose after HD on dialysis days.

750-1500mg IV q8h

General Information

  • Community acquired pneumonia with a macrolide

  • Intraabdominal infection

  • Epiglottitis

  • Allergy (immediate & delayed)

  • Positive Coombs

  • Cytopenias

  • GI upset

  • Diarrhea

  • Abnormal liver enzymes

No significant interactions.

Antimicrobial class: 2nd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic

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