Ceftazidime

C difficile risk
High
Oral Bioavailability
N/A

Dosing

1-2g IV q8h

eGFR 0 - 10eGFR 10 - 30eGFR 30 - 50eGFR > 502g IV q48-72h2g IV q24h2g IV q12h2g IV q8h

1g IV q24h

Dose after HD on dialysis days.

For serious infections can use 2g IV q24h.

2g IV q8h

General Information

Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.

Notable lack of gram positive activity versus other cephalosporins.

Allergy (immediate and delayed).

Note potential cross-reactivity with aztreonam based on side chain.

Antimicrobial class: 3rd generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate

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