1-2g IV q8h
eGFR 0 - 10eGFR 10 - 30eGFR 30 - 50eGFR > 502g IV q48-72h2g IV q24h2g IV q12h2g IV q8h
1g IV q24h
Dose after HD on dialysis days.
For serious infections can use 2g IV q24h.
2g IV q8h
Broad gram negative coverage including Pseudomonas, generally used for nosocomial infections including post-neurosurgical meningitis, or other infections based on susceptibilities.
Notable lack of gram positive activity versus other cephalosporins.
Allergy (immediate and delayed).
Note potential cross-reactivity with aztreonam based on side chain.
Antimicrobial class: 3rd generation Cephalosporin
Pregnancy category: B
Average serum half life: 2 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Therapeutic
Biliary penetration: Moderate