C difficile risk
Oral Bioavailability


1-2 g IV every 6-8 hr

CrCl > 50 ml/minCrCl 30-50 ml/minCrCl 10-29 ml/minCrCl 5-9 ml/minCrCl <5 ml/minNo dose adjustment necessary2 g IV every 8 hr2 g IV every 12 hr1 g every 12 hr1 g IV every 24 hr

2 g IV after each dialysis session. Maintenance dose as above based on estimated CrCl

General Information

Perioperative pophylaxis in patients undergoing uncontaminated GI surgery, abdominal or vaginal hysterectomy, or cesarean section


  • Periodic SCr


  • Hypersensitivity reaction

  • Diarrhea

  • INR (May enhance effects of warfarin)

  • GI effects, diarrhea

  • Hypersensitivity reaction

  • May enhance nephrotoxic effects of aminoglycosides

  • Enhances the anticoagulant effects of warfarin

Antimicrobial class: Cephalosporin (Second generation)

Average serum half life: 1.4 hr

Biliary penetration: Good

CSF penetration: Poor

Lung penetration: Good

Urine penetration: Good

Route of Elimination: Primarily urine

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