C difficile risk
Oral Bioavailability


1-2g IV q4-12h

eGFR 0 - 10 eGFR 10 - 50eGFR > 502g IV q24h2g IV q12h-24h2g IV q8-12h

1-2g IV q24h

Dosed after HD on dialysis days

2g IV q12h

General Information

Empiric therapy for:

  • Bacterial meningitis

  • Pneumonia (in combination with a macrolide)

  • Intra-abdominal infection including SBP

  • Musculoskeletal i.e. septic arthritis

  • Urinary tract infection

  • Rash

  • Localized phlebitis at injection site

  • Allergy

  • Positive Coombs test

  • Neutropenia

  • Abnormalities in liver enzymes

  • Diarrhea

  • CDI

Prefer ceftriaxone for CNS infection in renal failure.

Antimicrobial class: 3rd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 1.5 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate

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