Cefepime

C difficile risk
High
Oral Bioavailability
N/A

Dosing

2g IV q8-12h

eGFR 0 - 10eGFR 10 - 30eGFR 30 - 60eGFR > 601g IV q24h2g IV q24h2g IV q12h2g IV q8h

1g IV q24h

Dose post-HD on dialysis days

2g IV q8h

General Information

Broad spectrum antimicrobial with gram positive and gram negative coverage including Pseudomonas.

Used especially nosocomial infections involving resistant organisms

  • Allergy (immediate & delayed)

  • Positive Coombs

  • Cytopenias

  • Non-convulsive status epilepticus

Antimicrobial class: 4th generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic

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