Caspofungin

C difficile risk
Low
Oral Bioavailability
N/A

Dosing

70mg IV x 1 dose, then 50mg IV daily

Adult, moderate (Child-Pugh score B-C) 70 mg IV x 1, then 35 mg IV daily

No adjustments necessary

General Information

Caspofungin is often used in management of suspected and confirmed invasive fungal infections, particularly Candidiasis and Aspergillosis

  • Liver enzymes at baseline and every 1-2 weeks

  • Infusion-related reactions (rash, pruritis)

  • Phlebitis

  • Headache

  • Nausea and vomiting

  • Elevations in hepatic enzymes

Caspofungin has poor vitreous, CNS and urinary penetration. It should not be used for treatment of Candida urinary tract infections

Antimicrobial class: Echinocandin

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor

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