Aztreonam

C difficile risk
Medium
Oral Bioavailability
N/A

Dosing

2g IV q8h for severe infections

eGFR 0 - 10eGFR 10 - 50eGFR > 502g IV q24h3-4g IV daily divided q8-12h2g IV q8h

0.5-2g IV load then 500mg IV q12h

2g IV load then 1g IV q6h

General Information

Therapy of gram negative infections including Pseudomonas, particularly in patients with penicillin and cephalosporin allergy or when there is no alternative susceptible agent.

Nebulized form used in cystic fibrosis patients.

Empiric therapy for febrile neutropenia.

Monitor liver enzymes.

  • Elevated liver enzymes

  • Cytopenias

  • Eosinophilia

  • Phlebitis at injection site

  • Rash/allergy

  • CNS toxicity

No significant interactions.

Antimicrobial class: Monobactam

Pregnancy category: B

Average serum half life: 2 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Moderate

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