Ampicillin-Sulbactam

C difficile risk
Medium
Oral Bioavailability
N/A

Dosing

1.5-3 g IV every 6 hr

CrCl ≥ 30 ml/minCrCl 10-29 ml/minCrCl 5-14 ml/minNo dose adjustment necessary3 g IV every 12 hr3 g IV every 24 hr

3 g IV every 24 hr

3 g IV every 12-24 hr

General Information

Skin and soft tissue infections

Polymicrobial infections of the respiratory tract or abdomen

Lab In patients with preexisting hepatic impairment, periodic hepatic funtion monitoring

Clinical Hypersensitivity reactions

  • Allergy/Skin rash

  • Diarrhea

  • Pain at injection site/phlebitis

Allopurinol - increased rash

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

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