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Management of infections due to multi-drug resistant Enterobactericiae, Acinetobacter, and Pseudomonas on a case-by-case basis.
Severe infectious caused by multidrug-resistant Gram-negative organisms when other antimicrobial options are limited.
Infections due to non-MDR pathogens for which alternate therapy, particularly beta-lactam antibiotics, are available
Prophylaxis
Serum creatinine, BUN; urine output; signs of neurotoxicity
Nephrotoxicity in up to 20% of patients
Phlebitis at infusion sites
Neurotoxicity
Inhaled form: Possible bronchospasm, ARDS
Pregnancy category: C
Breastfeeding: No studies have evaluated serum levels or adverse effects in breastfed infants whose mothers were receiving colistimethate
Breastfeeding is acceptable with the use of inhaled colistin or colistimethate
Adapted from the UCLA Health Antimicrobial Stewardship Program