Contraindicated in patients with acute liver disease or previous isoniazid-associated hepatic injury.
Laboratory
Clinical
>10%:
Food reduces the rate and extent of absorption, Isoniazid should be taken at least 1hr before or 2hrs after meal.
Absorption readily absorbed
Distribution widely distributed in all fluids and tissue, pleural and ascitic fluid
Therapeutic level is attained in CSF
Pregnancy category C
Breastfeeding compatible
Adapted from the UCLA Health Antimicrobial Stewardship Program