Restricted
Serum electrolytes; renal function, liver function
Sodium content (320 mg per gram of IV fosfomycin) should be considered in patients requiring sodium restriction. Use with caution in patients with cardiac insufficiency, hypertension, hyperaldosteronism, hypernatremia, pulmonary edema, or hepatic cirrhosis.
A high sodium load may also result in decreased serum potassium level.
Assess electrolytes (sodium, potassium, and phosphate) and fluid balance regularly, in particular for patients receiving digoxin or when using the high-dose regimen (>16 g/day in adults
There are limited safety data for doses >16 g/day.
GI upset, especially diarrhea
Headache
Eosinophilia, neutropenia
Hypokalemia
Antimicrobial class: Phosphonic acid derivative
Pregnancy category: B
Breastfeeding: Compatible
Fosfomycin produces low levels in milk and is unlikely to be absorbed well by the infant
Average serum half life: 6 hours
Urine penetration: Therapeutic