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Fungicidal therapy of yeast/fungus/mold infection.
Invasive candidiasis, aspergillosis, cryptococcosis.
Visceral/mucocutaneous Leishmaniasis.
Induction therapy for dimorphic fungii (cocci, blasto, histo).
Not for use in urinary tract infection.
RECOMMENDED
Same toxicities as conventional Amphotericin B but with less frequency.
Nephrotoxicity ++
Anemia
Phlebitis
Arachnoiditis
Urinary retention
Paresthesias
Infusion related symptoms
Fever
Rigors
N/V
Headache
Electrolyte abnormalities
HypoK and HypoMg
Loss of bicarb
See additional information
Neuromuscular blocking agents, digoxin, antiarrhythmics:
Other nephrotoxic drugs:
Loop/thiazide diuretics, long term steroids, laxatives:
Lipid associated AmB is taken up preferentially by phagocytic cells and concentrated at sites of infection while minimizing renal exposure.
Precautionary measures for the prevention or treatment of infusion reaction are:
Pay careful attention to electrolyte and fluid status with boluses (usually 500mL) before and after infusion, as well as K and Mg supplementation PRN.
Antimicrobial class: Antifungal. Polyene. Lipid formulations designed to minimize toxicity
Average serum half life: 150 hours
Urine penetration: Poor
Lung penetration: Therapeutic
Biliary penetration: Therapeutic
Pregnancy: Category B
Breastfeeding: No information exists on the milk excretion of amphotericin B, as per Lact med Ref.