General Spectrum of Activity
Always use in combination with other agents
Inducer of PGP and many CYP enzymes including 3A4, and 2C9. Review patients medications carefully.
Should never be used as monotherapy, due to development of resistance.
May discolor bodily secretions (yellow-reddish). Caution in contact lens wearers.
Antimicrobial class: Antimycobacterial
Pregnancy category: C
Average serum half life: 3-4 hr
Biliary penetration: Therapeutic
CSF penetration: Therapeutic with inflamed meninges
Lung penetration: Therapeutic
Route of Elimination: Feces