Antimicrobials
Moxifloxacin

Moxifloxacin

Restricted

High
Excellent (90 to 100%)
See Additional Information

Spectrum of Activity

Dosing

General Information

  • Lower respiratory tract infections (CAP, HAP, aspiration)
  • Some intra-abdominal infections
  • CNS infection
  • Monitor QTc in patients with increased risk
  • QTc prolongation
  • Dysglycemia
  • Tendon rupture
  • GI intolerance
  • C. difficile colitis
  • Allergic reactions
  • Photosensitivity
  • CNS: Headache, malaise, insomnia, restlessness, dizziness, seizure
  • Weakness exacerbation in myasthenia gravis (avoid use)
  • Retinal detachment
  • Peripheral neuropathy
  • Increased hepatic enzymes
  • Interstitial nephritis
  • Avoid concurrent use with other drugs that prolong the QT interval.
  • Agents with Blood Glucose Lowering Effects - decreased blood sugar control may occur with quinolone use.
  • Cations/Vitamins and minerals - decreased absorption of quinolones (avoid concurrent administration).
  • Corticosteroids (systemic) - increased risk of tendonitis and tendon rupture.
  • NSAIDs - may increase risk of seizure.
  • Rifampin - decrease moxifloxacin levels.
  • Sevelamer - may decrease moxifloxacin absorption.
  • Warfarin - may increase INR with co-administration.

Moxifloxacin restricted to Infectious Diseases (ID)/Antimicrobial Stewardship Program (ASP) and Gastroenterology/Oncology within 48 hours of being dispensed.

Cost:

  • PO: $0.47/Dose; $2.35/5 Days
  • IV: $16.12/Dose; $80.60/5 Days

Antimicrobial class: 2nd Generation/Respiratory Fluoroquinolone

Pregnancy category: C

Average serum half life: 12 hours

Urine penetration: Poor

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Therapeutic