Antimicrobials
Linezolid

Linezolid

Restricted

Low
Excellent (90 to 100%)
See Additional Information

Spectrum of Activity

Dosing

General Information

  • Targeted or empiric therapy for serious resistant gram-positive infections including skin and soft tissue, and pneumonia.
  • Covers MRSA and VRE.
  • CBC (especially platelets) at least once/week
  • Visual testing for therapy >3 months or if symptoms develop on therapy
  • GI intolerance
  • Serotonin syndrome
  • Rash
  • Elevated liver enzymes
  • Lactic acidosis
  • Myelosuppression (usually with >2weeks therapy)- reversible
  • Peripheral/optic neuropathy with prolonged courses
  • C. difficile colitis
  • Seizure
  • Hypoglycemia
  • Insulin/hypoglycemics - hypoglycemia risk.
  • SSRI and other serotonergics/MAOIs - increased risk of serotonin syndrome.
  • Rifampin decreases linezolid levels.

Restricted to Infectious Diseases (ID)/Antimicrobial Stewardship Program (ASP).

Bacteriostatic.

Cost:

  • PO: $27.06/Dose; $270.60/5 Days
  • IV: $11.17/Dose; $111.70/5 Days

Antimicrobial class: Oxazolidinone

Pregnancy category: C

Average serum half life: 5 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic