Antimicrobials
Fluconazole

Fluconazole

Low
Excellent (90 to 100%)
See Additional Information

Spectrum of Activity

Dosing

General Information

  • Candida infections both mucocutaneous and invasive - i.e. Candidemia
  • Cryptococcus and Coccidioides infections
  • Antifungal prophylaxis in immunocompromised
  • Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement.
  • Liver function.
  • Drug interactions
  • GI upset
  • QTc prolongation
  • Hepatic enzyme abnormalities
  • Rash
  • Alopecia
  • Many via CYP450.
    • Suggest review specific patient medications.
  • Fluconazole increases levels of phenytoin, carbamazepine, cyclosporine, some statins, tacrolimus, warfarin, oral hypoglycemics, and many others.
  • May decrease efficacy of clopidogrel.
  • Risk when combining with other QTc prolonging medications.

Cost:

  • PO: $1.37/Dose; $6.85/5 Days
  • IV: $21.12/Dose; $105.60/5 Days

Antimicrobial class: Triazole antifungal

Pregnancy category: C to D (higher doses)

Average serum half life: 30 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic