Antimicrobials
Ertapenem

Ertapenem

Restricted

High
N/A
$32.74/Dose $163.70/5 Days

Spectrum of Activity

Dosing

General Information

  • Targeted therapy of ESBL infections and other resistant gram negative infections.
  • Empiric therapy when broad spectrum of carbapenems is desired without the need for anti-pseudomonal activity.
  • Renal, hepatic, and CBC periodically
  • GI disturbance
  • C. difficile colitis
  • Allergic reactions (immediate or delayed)
  • Drug rash
  • Cytopenias
  • Liver enzyme abnormalities
  • Neuro: altered mental status, seizures
  • Valproic acid - may decrease valproate levels and decrease seizure threshold.
  • Tacrolimus (Systemic) - may increase the serum concentration of Tacrolimus (Systemic).
  • Not compatible with dextrose.

Restricted to Infectious Diseases (ID)/Antimicrobial Stewardship Program (ASP).

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 4 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Moderate