Antimicrobials
Doxycycline

Doxycycline

Low
Excellent (90 to 100%)
$0.29/Dose $2.9/5 Days

Spectrum of Activity

Dosing

General Information

  • Skin and soft tissue infections
  • Community acquired pneumonia
  • MRSA infections
  • Malaria prophylaxis
  • Lyme disease
  • Zoonoses
  • GI intolerance
  • Esophageal ulceration (ensure adequate fluid intake with administration)
  • Photosensitivity
  • Teeth staining
  • Elevated liver enzymes
  • Polyvalent cations/vitamins and minerals such as Al, Ca, Fe, Mg, Zn (antacids, dairy products, iron supplements, etc) - decreased absorption (avoid concurrent administration)
  • Some anticonvulsants (e.g. carbamazepine, phenytoin) can decrease doxycycline levels
  • May increase digoxin levels
  • Increased INR with warfarin

Doxycycline is a good option for atypical pneumonia coverage if QT prolongation is a concern.

Doxycycline IV is only available through Special Access Program (SAP).

Antimicrobial class: Tetracycline

Pregnancy category: D

Average serum half life: 18 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Limited