Restricted
Limitations of use: CANNOT be used in pneumonia, as it is inactivated by lung surfactant in alveoli.
Statins - holding statin is recommended during daptomycin therapy, due to the potential for CK elevation, myopathy.
Higher doses used for endovascular infection.
Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection.
Restricted to Infectious Diseases (ID)/Antimicrobial Stewardship Program (ASP) within 48 hours of being dispensed.
Antimicrobial class: Cyclic Lipopeptide
Pregnancy category: B
Average serum half life: 8-9 hours
Urine penetration: Therapeutic
Lung penetration: Poor
CSF penetration: Poor