Antimicrobials
Cefotaxime

Cefotaxime

High
N/A

Dosing

General Information

  • Pneumonia
  • Urinary tract infection
  • Gynecologic infections
  • Intra-abdominal infections including SBP
  • Bone and joint infections
  • Bacterial meningitis
  • Renal function
  • CBC
  • Localized phlebitis at infusion site
  • Diarrhea
  • C. difficile colitis
  • Allergic reactions
  • Rash
  • Drug fever
  • Cytopenias
  • Interstitial nephritis
  • Liver dysfunction
  • CNS: seizures (increased risk with high dose and renal failure)

Warfarin - anticoagulation effect may be enhanced.

Prefer ceftriaxone for CNS infection in renal failure.

Note: cefotaxime and ceftriaxone equivalent spectrum of activity for gram positive organisms.

Antimicrobial class: 3rd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 1.5 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Penetrates CSF best when meninges are inflamed

Biliary penetration: Moderate