Restricted
Frequency depends on course, but daily reasonable during initiation.
Infusion related symptoms (slow down infusion)
Electrolyte abnormalities
Main concern is concomitant nephrotoxins. Use should be minimized during amphotericin therapy.
Increased digoxin toxicity with hypokalemia.
Premedication with acetaminophen, diphenhydramine and/or hydrocortisone are used. Meperidine may be used for rigors.
Pay careful attention to electrolyte and fluid status with boluses (usually 500mL) before and/or after infusion, as well as K and Mg supplementation PRN.
Lipid-based and conventional amphotericin B (deoxycholate) formulations are not interchangeable and have different dosing recommendations.
Fungizone™️ restricted to Infectious Diseases (ID)/Antimicrobial Stewardship Program (ASP) and Oncology/Critical Care within 48 hours of being dispensed.
Antimicrobial class: Antifungal, Polyene
Pregnancy category: B
Average serum half life: 24 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Poor