Infective Endocarditis (IE)
Non-HACEK Gram-Negative Bacilli

Non-HACEK Gram-Negative Bacilli

Note

Consult Infectious Disease for antibiotic regimen

  • Enterobacteriaceae and Pseudomonas
  • Predominantly E. coli and P. aeruginosa
  • High prevalence of PVE

Cardiac surgery may be reasonable in combination with prolonged course of combined antibiotic therapy for most patients with IE caused by non-HACEK gram-negative aerobic bacilli, particularly P. aeruginosa

Recommended Treatment

Beta Lactam (Penicillins, Cephalosporins or Carbapenems)

PLUS

Aminoglycoside

OR

Fluoroquinolone

Duration of Therapy

6 weeks