Cloxacillin 2g IV q4h x ≥6 weeks
PLUS
Rifampin 300mg IV/PO q8h (delay initiation until 3-5 days after initiation of other agents) x ≥6 weeks
Gentamicin
OR
Fluoroquinolone
If organism resistant to all available aminoglycosides, and is susceptible to a fluoroquinolone
CeFAZolin 2g IV q8h
CeFAZolin may be substituted for cloxacillin in the regimen above
Vancomycin
Adult Aminoglycoside Dosing and Therapeutic Monitoring
Vancomycin Dosing