Staphylococcal Endocarditis
MSSA

MSSA

Recommended Treatment

PLUS

PLUS

  • 1mg/kg, dosing interval based on CrCl x first 2 weeks of therapy
  • Should not be used in patients with CrCl <30mL/min
  • If resistant to gentamicin, then substitute with a susceptible aminoglycoside

OR

Fluoroquinolone

If organism resistant to all available aminoglycosides, and is susceptible to a fluoroquinolone

Beta-Lactam Allergy (Non-Anaphylaxis)

CeFAZolin may be substituted for cloxacillin in the regimen above

Beta Lactam Anaphylaxis

  • 25mg/kg IV LOAD, then maintenance dose based on CrCl (see vancomycin monitoring) x 6 weeks
  • Serum trough target levels = 10-20mg/L