Insufficient evident to support the use of probiotics for primary prevention of CDI
Saccharomyces boulardii or any other probiotics should NOT be used if patient is immunocompromised as there is potential for organisms in probiotic formulations to cause infections in hospitalized patients (IDSA)
Up to the treating clinician's judgment as to whether a patients has mild, moderate, or severe disease
Typical manifestations:
Acute diarrhea (≥ 3 loose stools in 24 hours) with no obvious alternative explanation
Positive diagnostic laboratory assay
Empiric treatment is reasonable in the setting of very high clinical suspicion for CDI (e.g. patients with symptoms of severe or fulminant colitis), pending results of diagnostic testing
Treatment is NOT indicated in patients who have a positive diagnostic laboratory assay but do not have diarrhea or other CDI disease manifestations (asymptomatic carriage is common)