Restricted
See Restricted Antimicrobials Approved Indications of Use
Therapeutic drug monitoring may be helpful to ensure adequate concentrations and exclude toxicity (Discuss with ID). When voriconazole is taken concomitantly with other drugs, dose adjustment of voriconazole or the concomitant drug may be required due to drug interactions.
QTc interval in patients at elevated risk.
Monitor hepatic profile.
Please see attached for guidance on dose timing and actionable steps.
CYP450 interactions ++.
Other QTc prolonging agents.
Recommend review of patient medications due to high frequency of significant interactions. Consult pharmacy.
LU code for outpatient use:
Antimicrobial class: Triazole antifungal, Second generation
Pregnancy category: D
Average serum half life: Variable, dose-dependent Steady state is achieved by Day 3 when an IV loading dose is administered and between days 5 and 8 if no loading dose is given
CSF penetration: Therapeutic (>50%)
Lung penetration: Therapeutic
Urine penetration: Poor
Vitreous penetration: Therapeutic (>50%)