Antimicrobials
MetroNIDAZOLE

MetroNIDAZOLE

Low
Excellent
IV: $$ PO: $

Spectrum of Activity

Dosing

General Information

Suspected or confirmed anaerobic infections including:

  • Intra-abdominal

  • Biliary

  • Central nervous system

  • Clostridium difficile

  • Giardia

  • Pelvic infections

Also used in:

  • Crohns disease

  • Bacterial vaginosis

Assess for peripheral/optic neuropathy with prolonged therapy (>6wks) or if symptoms develop.

  • GI symptoms common - Especially nausea/vomiting and metallic taste

  • Peripheral/optic neuropathy with extended therapy

  • Disulfiram-like reaction (severe vomiting)

  • Rare neurotoxicity including aseptic meningitis and encephalopathy

Ethanol - Disulfiram-like reaction.

Increases levels of:

  • Cyclosporine
  • Lithium
  • Warfarin
  • Phenobarbital
  • Phenytoin

Antimicrobial class: Nitroimidazole

Pregnancy category: B

Average serum half life: 10 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Poor