Bacteremia caused by methicillin resistant S. aureus with intermediate susceptibility to vancomycin (MIC≥ 2mcg/mL).
Should NOT be used for the treatment of bacteremia associated with pneumonia or central nervous infection.
Creatine kinase weekly.
GI side effects common
Rash
Phlebitis
Increased INR
Myopathy including rhabdomyolysis
Statins and fibrates - Increased myopathy.
Monitor creatine kinase or hold while on daptomycin therapy.
Higher doses used for endovascular infection.
Recommend Infectious Disease Consult.
Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection.
Antimicrobial class: Cyclic Lipopeptide
Pregnancy category: B
Average serum half life: 9 hours
CSF penetration: Poor
Lung penetration: Poor
Urine penetration: Therapeutic
Antimicrobials
