Antimicrobials
Clarithromycin

Clarithromycin

Medium
Moderate
$

Spectrum of Activity

Dosing

General Information

  • CAP

  • Pertussis

  • URTI

  • H. pylorI and mycobacterial infections (in combination)

Monitor QTc in patients with increased risk.

  • Neutropenia

  • GI upset

  • Prolongation of QTc interval

  • Drug interactions

Recommend review of patient medications due to high frequency of significant interactions.

  • CYP450 interactions ++
  • Other QTc prolonging agents
  • Statins - increased rhabdo
  • CCBs - hypotension, AKI
  • Colchicine - increased bone marrow toxicity
  • Increased anticonvulsant levels
  • Increased tacrolimus levels

Antimicrobial class: Macrolide

Pregnancy category: C

Average serum half life: 5 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor