Antimicrobials
CeFAZolin

CeFAZolin

Medium
N/A
$

Dosing

General Information

  • Skin and soft tissue infection (e.g. cellulitis, osteomyelitis)

  • Surgical prophylaxis

  • Susceptible Staphylococcal, Streptococcal and Gram negative infections

  • Cardiovascular infections including endocarditis

  • Some intra-abdominal infections

  • UTI

  • Allergy (immediate or delayed)

  • Can cause positive Coombs, cytopenias, and hepatic and renal laboratory abnormalities

  • CNS: seizure risk increases

  • GI disturbances (nausea, diarrhea)

Probenecid - prolonged half-life. Drug interaction has been used therapeutically to give once daily cefazolin.

May increase levels/effects of: fosphenytoin; Phenytoin; Rifampin; Vitamin K antagonists (including warfarin).

May decrease levels/effects of: BCG vaccine; Cholera vaccine; Typhoid vaccine;, Sodium Picosulfate; Estriol; Lactobacillus.

Cefazolin (urinary) sensitivity correlates to use of cephalexin and cefprozil when used for treatment of uncomplicated UTIs due to E.coli, K. pneumoniae, and P. mirabilis. It DOES NOT predict cefazolin for therapy of infections other than uncomplicated UTIs.

Antimicrobial class: 1st Generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Therapeutic