1-2g IV q4-6hMeningitis or Endocarditis
2g IV q4h
CrCl ≥ 50mL/min
Administer dose after dialysis on dialysis daysPeritoneal Dialysis
Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria.
Allergy and rash as for all beta-lactams.
EBV related rash (not allergy).
Rare: cytopenias, +ve Coombs.
Increased risk of rash with allopurinol.
Antimicrobial class: Aminopenicillin
Pregnancy category: B
Average serum half life: 1 hour
Biliary penetration: Therapeutic
CSF penetration: Therapeutic with inflamed meninges
Lung penetration: Therapeutic
Urine penetration: Therapeutic