Antimicrobials
Ampicillin

Ampicillin

C difficile risk
Low
Oral Bioavailability
N/A
Cost
$$

Dosing

Standard Dose

  • 1-2g IV q4-6hMeningitis or Endocarditis

  • 2g IV q4h

CrCl ≥ 50mL/min

Usual Dose Reduce Dose
1-2g IV q6h 1-2g IV q6h
2g IV q4h 2g IV q4h
Usual Dose Reduce Dose
1-2g IV q6h 1-2g IV q8h
2g IV q4h 2g IV q6h
Usual Dose Reduce Dose
1-2g IV q6h 1-2g IV q12h
2g IV q4h 2g IV q8h
Usual Dose Reduce Dose
1-2g IV q6h 1-2g IV q24h
2g IV q4h 2g IV q12h
Usual Dose Reduce Dose
1-2g IV q6h 1-2g IV q24h
2g IV q4h 2g IV q12h

Administer dose after dialysis on dialysis daysPeritoneal Dialysis

Usual Dose Reduce Dose
1-2g IV q6h 1-2g IV q24h
2g IV q4h 2g IV q12h

General Information

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections especially Enterococcus and Listeria.

Allergy and rash as for all beta-lactams.

EBV related rash (not allergy).

Rare: cytopenias, +ve Coombs.

Increased risk of rash with allopurinol.

Antimicrobial class: Aminopenicillin

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Therapeutic with inflamed meninges

Lung penetration: Therapeutic

Urine penetration: Therapeutic