Antimicrobials
Amoxicillin-Clavulanate

Amoxicillin-Clavulanate

Medium
Excellent
$

Spectrum of Activity

Dosing

General Information

Prophylaxis/treatment of bite wounds.

Polymicrobial infections of the respiratory tract or abdomen.

Skin and soft tissue infections.

For prolonged therapy, monitor liver enzymes and function.

  • Allergy/rash (immediate or delayed)

  • Note EBV related rash

  • Cytopenias

  • Diarrhea

  • Hepatotoxicity due to clavulinate - usually mild, liver failure is rare.

Increased risk of rash with allopurinol.

Note: Most gram positive organisms (e.g. Enterococci and Streptococci) do not produce a beta-lactamase and the addition of Clavulanate to Amoxicillin is not necessary.

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic