Purulent Skin & Soft Tissue Infection (Staphylococcus)

Purulent Skin & Soft Tissue Infection (Staphylococcus)

Empiric Treatment

  • No signs and symptoms of systemic infection
    • Carbuncle
    • Abscesses
    • Furuncles
    • Erysipelas
  • Presence of systemic signs and symptoms of infection
    • Temperature > 38°C or < 36°C
    • Tachypnea > 24 breaths/min
    • Tachycardia > 90 bpm
    • WBC > 12,000 or < 4,000 mm3


  • Hypotension
  • Failure of previous antibiotic therapy
  • Markedly impaired host defences

More Information

  1. Catherine Liu, Arnold Bayer, Sara E. Cosgrove, Robert S. Daum, Scott K. Fridkin, Rachel J. Gorwitz, Sheldon L. Kaplan, Adolf W. Karchmer, Donald P. Levine, Barbara E. Murray, Michael J. Rybak, David A. Talan, Henry F. Chambers. Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections in Adults and Children. Clinical Infectious Diseases. 2011. Accessed November 11, 2019:e18-e55.
  2. Dennis L. Stevens, Alan L. Bisno, Henry F. Chambers, E. Patchen Dellinger, Ellie J. C. Goldstein, Sherwood L. Gorbach, Jan V. Hirschmann, Sheldon L. Kaplan, Jose G. Montoya, James C. Wade. Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases. 2014. Accessed November 11, 2019:e10-e52.