Penicillin Ordered

• Contact prescriber for alternative or desensitization/challenge if PCN is necessary for treatment

Cephalosporin Ordered

• May use cephalosporin with dissimilar side chain

Penicillin Ordered

• Contact prescriber for alternative or desensitization/challenge if PCN is necessary for treatment

Cephalosporin Ordered

• May use cephalosporin

Penicillin Ordered

• May use penicillin with dissimilar side chain

Cephalosporin Ordered

• May use cephalosporin with dissimilar side chain

• Cefazolin has no like side-chains with any PCN or cephalosporins

• Cefazolin plus metronidazole (over 30 min) may be substituted for cefoxitin in penicillin allergic (IgE) patients

• Ampicillin 6

• Cefaclor 6/7

• Cefadroxil 6/7

• Cefprozil 6/7

• Cephalexin 6/7

• Amoxicillin 6

• Cefaclor 6/7

• Cefadroxil 6/7

• Cefprozil 6/7

• Cephalexin 6/7

• Amoxicillin 6/7

• Ampicillin 6/7

• Cefadroxil 7

• Cefprozil 7

• Cephalexin 7

• Amoxicillin 6/7

• Ampicillin 6/7

• Cefaclor 7

• Cefprozil 7

• Cephalexin 3,7

• Cefixime 3

• Cefotaxime 7

• Cefpodoxime 7

• Ceftizoxime 7

• Ceftriaxone 7

• Cefdinir 3

• Cefepime 7

• Cefpodoxime 7

• Ceftizoxime 7

• Ceftriaxone 7

• No side chain similarities reported

• Cefuroxime 3

• Penicillin G 6/7

• Cefepime 7

• Cefotaxime 7

• Ceftizoxime 7

• Ceftriaxone 7

• Amoxicillin 6/7

• Ampicillin 6/7

• Cefaclor 7

• Cefadroxil 7

• Cephalexin 7

• Aztreonam

• Ceftizoxime 3

• Cefepime 7

• Cefotaxime 7

• Cefpodoxime 7

• Ceftibuten 3

• Ceftriaxone 7

• Cefepime 7

• Cefotaxime 7

• Cefpodoxime 7

• Ceftizoxime 7

• Cefoxitin 3

• Amoxicillin 6/7

• Ampicillin 6/7

• Cefaclor 7

• Cefadroxil 3,7

• Cefprozil 7

• Cefoxitin 6/7

J Am Pharm Assoc. 2008;48:530–540.