Clostridium perfringens

Clostridium perfringens


General Information

Penicillin G with or without Clindamycin

  • Ampicillin/sulbactam
  • Metronidazole
  • Piperacillin/tazobactam
  • Meropenem

Anaerobic spore forming gram positive bacilli, box-car shaped

  • Environmental (soil, water) organism as well as human/animal digestive tract
  • Associated with penetrating wounds with environmental exposure
  • Gas gangrene/Clostridial myonecrosis
  • Necrotizing skin and soft tissue infection
  • Septic abortion, tubo-ovarian abscesses, uterine gas gangrene
  • Intra-abdominal abscess
  • Fatal bacteremia with massive exotoxin-mediated hemolysis
  • Foodborne self-limited gastrointestinal illness
  • Surgical debridement of devitalized tissue crucial