Pathogens
Acinetobacter baumannii

Acinetobacter baumannii

Susceptibilities

General Information

Susceptible Acinetobacter: ampicillin/sulbactam

Multidrug-Resistant Acinetobacter (defined as non-susceptible to BOTH ampicillin/sulbactam AND meropenem AND at least one of the following: cephalosporins, tetracyclines, fluoroquinolones, aminoglycosides): 

  1. Cystitis
    1. Single-dose amikacin
    2. TMP/SMX
    3. Ciprofloxacin
    4. Levofloxacin 
  2. Pyelonephritis or complicated UTI
    1. Amikacin
    2. TMP/SMX
    3. Ciprofloxacin
    4. Levofloxacin 
  3. Infection outside of the urinary tract
    1. Meropenem + minocycline +/- ampicillin/sulbactam (add third agent in the setting of septic shock or clinical instability)

Susceptible Acinetobacter

  • Meropenem
  • TMP/SMX
  • Levofloxacin, ciprofloxacin

Multidrug-Resistant Acinetobacter (defined as non-susceptible to BOTH ampicillin/sulbactam AND meropenem AND at least one of the following: cephalosporins, tetracyclines, fluoroquinolones, aminoglycosides):

  1. Infection outside of the urinary tract:
    1. Cefiderocol+ minocycline + ampicillin/sulbactam (add third agent in the setting of septic shock or clinical instability)

Resistant aerobic non-fermenting gram negative rod

  • Generally causes nosocomial infection in North America and can occur in outbreaks in this setting

  • Infections seen in military personnel in war zones as well as natural disaster settings, e.g. tsunami/earthquake

  • VAP

  • Bloodstream infections

  • Biofilm infections of prosthetic devices

  • Wound infection/SSTI

  • CAUTI