Minocycline
Minocycline

Minocycline

Restricted

Low
Excellent (90 to 100%)
PO: $1.74/dose IV: $175.34/dose

Spectrum of Activity

General Information

IV Formulation: Tier 4

  • Increased LFTs
  • Absorption: Oral: Well absorbed
  • Distribution: Widely distributed to most body fluids, bile, and tissues; poor CNS penetration; deposits in fat for extended periods; Vd: 0.14 to 0.7 L/kg
  • Protein binding: 55% to 96%
  • Metabolism: Hepatic to inactive metabolites
  • Bioavailability: 90% to 100%
  • Half-life elimination: IV: 15 to 23 hours; 11 to 16 hours (hepatic impairment); 18 to 69 hours (renal impairment); Oral: 16 hours (range: 11 to 17 hours)
  • Excretion: Urine 5% to 12% excreted unchanged; feces (20% to 34%)