See Lexicomp
Sporanox
Absorption:
Distribution (Vd): >700 L
Protein binding, plasma: 99.8%; metabolite hydroxy-itraconazole: 99.6%
Metabolism: Extensively hepatic via CYP3A4 into >30 metabolites including hydroxy-itraconazole (major metabolite); appears to have in vitro antifungal activity. Main metabolic pathway is oxidation; may undergo saturation metabolism with multiple dosing
Bioavailability: ~55% increases by 30% under fasted conditions (oral solution); Oral solution has a higher degree of bioavailability (149% ± 68%) relative to oral capsules
Half-life elimination: 16 to 28 hours, Multiple doses: 34 to 42 hours
Time to peak, plasma: Capsules/tablets: 2 to 5 hours; Oral solution: 2.5 hours
Excretion: Urine (<1% active drug, 35% as inactive metabolites); feces (54%; ~3% to 18% as unchanged drug)