Restricted
Renal function
Hepatic function
CBC
Tier 3
Seizures
Increased LFTs
See Lexicomp
Primaxin
Protein binding: Imipenem: ~20%; cilastatin: ~40%
Metabolism: Imipenem is metabolized in the kidney by dehydropeptidase I; cilastatin prevents imipenem metabolism by this enzyme
Half-life elimination: Prolonged with renal impairment; Adults: ~60 minutes
Excretion: Urine (~70% as unchanged drug)