Antimicrobials
Imipenem/cilastatin

Imipenem/cilastatin

Restricted

High
N/A
$$ ($26-100/day)

Spectrum of Activity

General Information

  • Renal function

  • Hepatic function

  • CBC

  • Seizures

  • Increased LFTs

Primaxin

  • Protein binding: Imipenem: ~20%; cilastatin: ~40%

  • Metabolism: Imipenem is metabolized in the kidney by dehydropeptidase I; cilastatin prevents imipenem metabolism by this enzyme

  • Half-life elimination: Prolonged with renal impairment; Adults: ~60 minutes

  • Excretion: Urine (~70% as unchanged drug)