Antimicrobials
Ganciclovir

Ganciclovir

Restricted

N/A
N/A
$$ ($26-100/day)

Spectrum of Activity

General Information

  • CBC with differential

  • Serum creatinine

  • Pregnancy test prior to initiation in females of reproductive potential

  • Pancytopenias (thrombocytopenia, leukopenia, neutropenia, anemia)

  • Nephrotoxicity

  • Impairment of fertility

  • Fetal toxicity

  • Hiperhydrosis

  • Diarrhea

  • Anorexia

  • Vomiting

  • Fever

  • Chills

Cytovene

  • Distribution (Vd): 0.74 ± 0.15 L/kg; widely to all tissues including CSF and ocular tissue

  • Protein binding: 1% to 2%

  • Half-life elimination: Mean: IV: 3.5 ± 0.9 hours; Oral: 4.8 ± 0.9 hours; CrCl <25 mL/minute: 10.7 ± 5.7 hours

  • Excretion: Urine (80% to 99% as unchanged drug)