Antimicrobials
Ceftolozane/Tazobactam

Ceftolozane/Tazobactam

Restricted

High
N/A
$$$$ ($201-$500/day)

Spectrum of Activity

General Information

  • Renal function
  • Increased serum transaminases
  • Distribution: Vd: Ceftolozane: 13.5 L; Tazobactam: 18.2 L
  • Protein binding: Ceftolozane: 16% to 21%; Tazobactam: 30%
  • Metabolism: Ceftolozane: Not metabolized; Tazobactam: Hydrolyzed to inactive metabolite
  • Half-life elimination: Ceftolozane: ~3 to 4 hours; Tazobactam: ~2 to 3 hours
  • Excretion: Ceftolozane: Urine (>95% as unchanged drug); Tazobactam: urine (>80% as unchanged drug)