Antimicrobials
Voriconazole

Voriconazole

N/A
Excellent (90 to 100%)
IV: $27.24/dose PO: $18.16/dose

Spectrum of Activity

Dosing

General Information

  • Therapeutic drug monitoring
  • QTc
  • LFTs
  • Acute kidney injury
  • QTc prolongation
  • Photosensitivity
  • Alopecia
  • Skin reactions, including TEN and DRESS
  • Hepatotoxicity
  • Visual disturbances
  • Optic neuritis, color changes
  • Peripheral neuropathy
  • Encephalopathy
  • Periosteal disease
  • Hyperkalemia

See Lexicomp; significant drug-drug interactions

  • Distribution: Extensive tissue distribution; CSF concentration ~50% of plasma concentration; Vd: 4.6 L/kg
  • Protein binding: 58%
  • Metabolism: Hepatic, via CYP2C19 (major pathway) and CYP2C9 and CYP3A4; saturable
  • Bioavailability: 96%
  • Half-life elimination: Variable, dose-dependent. Steady-state is achieved by day 3 when an IV loading dose is administered and between days 5 and 8 if no loading dose is used
  • Time to peak: Oral: 1-2 hours
  • Excretion: Urine (<2% as unchanged drug)