Antimicrobials
Vancomycin IV

Vancomycin IV

Low
N/A
$ (<$25/day)

Spectrum of Activity

Dosing

General Information

  • Renal function
  • Therapeutic drug monitoring
  • Auditory exams with prolonged therapy
  • Nephrotoxicity
  • Drug-induced immune thrombocytopenia
  • Neutropenia
  • Agranulocytosis
  • Ototoxicity
  • Hypersensitivity reactions
  • Skin reactions, including Stevens-Johnson syndrome
  • Infusion-related reactions (histamine release- slow down infusion)

Vancocin

  • Distribution: Distributes widely in body tissue and fluids, except for CSF; Vd: 0.4 to 1 L/kg, 0.3 to 0.5 L/kg in patients who are morbidly obese
  • Protein binding: ~55%
  • Metabolism: No apparent metabolism
  • Half-life elimination: Biphasic: Terminal: 4 to 6 hours; significantly prolonged with renal impairment
  • Excretion: Primarily via glomerular filtration; IV: Urine (75% as unchanged drug in the first 24 hours)
  • Clearance: 1.6 to 6.2 L/hour; patients who are obese: ~6 L/hour (rarely exceeds 9 L/hour)