In general, aminoglycosides are used in combination with a β-lactam antibiotic and are not used as monotherapy in the treatment of infections other than cystitis or pyelonephritis.
Renal function
Auditory exam with prolonged therapy
Therapeutic drug monitoring
Tier 2l
Nephrotoxicity
Ototoxicity
Neuromuscular blockade (avoid in patients with myasthenia gravis)
See Lexicomp
Distribution: Distributes to extracellular fluid, including serum, abscesses, ascitic, pericardial, pleural, synovial, lymphatic, and peritoneal fluids; poor penetration into CSF, eye, bone, prostate; Vd 0.2-0.3L/kg
Protein binding: <30%
Half-life elimination: 2-3 hours
Excretion: Urine, 90-95% within 24 hours