Tigecycline
Tigecycline (NF)

Tigecycline (NF)

Restricted

Low
N/A
$$ ($26-100/day)

Spectrum of Activity

General Information

  • LFTs
  • Coagulation parameters
  • Increased mortality
  • Diarrhea
  • Nausea
  • Vomiting
  • Coagulopathy
  • Increased LFTs
  • Pancreatitis
  • Distribution: Vd: 7 to 9 L/kg; extensive tissue distribution; distributes into gallbladder, lung, and colon
  • Protein binding: 71% to 89%
  • Metabolism: Hepatic, via glucuronidation, N-acetylation, and epimerization to several metabolites, each <10% of the dose
  • Half-life elimination:

    • Single dose: 27 hours
    • Multiple doses: 42 hours; increased by 23% in moderate hepatic impairment and 43% in severe hepatic impairment
  • Excretion: Feces (59%, primarily as unchanged drug); urine (33%, with 22% of the total dose as unchanged drug)

  • Clearance: Reduced by 25% in patient with moderate hepatic impairment and 55% in severe hepatic impairment