Antimicrobials
Micafungin

Micafungin

Restricted

N/A
N/A
$$$ ($101-200/day)

Spectrum of Activity

General Information

  • LFTs
  • Phlebitis
  • Vomiting
  • Diarrhea
  • CBC
  • Increased liver enzymes
  • Vomiting, diarrhea
  • Phlebitis
  • Anemia

Mycamine

  • Distribution: Distributes into lung, liver, and spleen; minimally to CNS and eyes; Vd: 0.39 +/- 0.11 L/kg
  • Protein Binding: >99% to albumin
  • Metabolism: Hepatic to M-1, catechol form by arylsulfatase; further metabolized to M-2, methoxy form by catechol-O-methyltransferase; hydroxylation to M-5 by CYP3A
  • Half-life: 11-21 hours
  • Excretion: Primarily feces (71%); urine (<1%, unchanged)
  • Clearance: ~0.3 mL/minute/kg