Distribution: Distributes into lung, liver, and spleen; minimally to CNS and eyes; Vd: 0.39 +/- 0.11 L/kg
Protein Binding: >99% to albumin
Metabolism: Hepatic to M-1, catechol form by arylsulfatase; further metabolized to M-2, methoxy form by catechol-O-methyltransferase; hydroxylation to M-5 by CYP3A