Monitor QTc
LFTs
Renal function
Drug/drug interactions (though to a lesser extent than many azoles)
QTc prolongation
Liver enzyme abnormalities
Drug/drug interactions
Alopecia
Headache
See Lexicomp
Diflucan
Absorption: Well absorbed; food does not affect extent of absorption
Distribution (Vd):
Plasma protein binding: 11% to 12%
Bioavailability: Oral: >90%
Half-life elimination: Normal renal function: ~30 hours (range: 20 to 50 hours); Elderly: 46.2 hours
Time to peak, serum: 1 to 2 hours
Excretion: Urine (80% as unchanged drug)