Antimicrobials
Fluconazole

Fluconazole

None
Excellent (90 to 100%)
<$25 per day

Spectrum of Activity

Dosing

General Information

  • Monitor QTc

  • LFTs

  • Renal function

  • Drug/drug interactions (though to a lesser extent than many azoles)

  • QTc prolongation

  • Liver enzyme abnormalities

  • Drug/drug interactions

  • Alopecia

  • Headache

Diflucan

  • Absorption: Well absorbed; food does not affect extent of absorption

  • Distribution (Vd):

    • ~0.6 L/kg; good penetration into CSF, eye, peritoneal fluid, sputum, skin, and urine
    • CSF:blood level ratio: Normal meninges: 50% to 90%; Inflamed meninges: ~80%
  • Plasma protein binding: 11% to 12%

  • Bioavailability: Oral: >90%

  • Half-life elimination: Normal renal function: ~30 hours (range: 20 to 50 hours); Elderly: 46.2 hours

  • Time to peak, serum: 1 to 2 hours

  • Excretion: Urine (80% as unchanged drug)