Antimicrobials
Ertapenem

Ertapenem

Restricted

High
N/A
$$ ($26-$100/day)

Spectrum of Activity

General Information

  • Valproate Products: Carbapenems may decrease the serum concentration of Valproate Products
    • Management:
      • Concurrent use of carbapenem antibiotics with valproic acid is generally not recommended
      • Alternative antimicrobial agents should be considered, but if a concurrent carbapenem is necessary, consider additional anti-seizure medication
  • Distribution: Vd:~0.12 L/kg
  • Protein binding: 85%-95%
  • Metabolism: Non-CYP-mediated hydrolysis to inactive metabolite
  • Half-life elimination: ~4 hours
  • Excretion: Urine (~80% as unchanged drug and metabolite); feces (~10%)